Current Optics and Photonics
Vol. 8 No. 4 (Aug. 2024)
한국광학회지
Vol. 35 No. 4(Aug. 2024)
K-Light
vol. 7, no. 3(Jul. 2024)
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[하이라이트 논문] 한국광학회지 Vol. 35 No.4 (2024 August)
Hyperlens and Metalens-based Biomedical Imaging
하이퍼렌즈 및 메타렌즈 기반 바이오메디컬 이미징
박혜미1,2 *ㆍ조용재1 *ㆍ김인기1,2†
한국광학회지 Vol. 35 No.4 (2024 August) pp. 135-142
DOI: https://doi.org/10.3807/KJOP.2024.35.4.135
Fig. 1 Examples of metamaterials operating at various wavelengths. The working mechanism and operation wavelength vary depending on the materials and structures. (a) V-shaped antenna metamaterial fabricated on a silicon wafer. Reprinted with permission from N. Yu et al. Science 2011; 334; 333-337. Copyright © 2011, The American Association for the Advancement of Science [7] . (b), (c) Scanning electron microscope images of square-shaped crystalline silicon metamaterials. Reprinted with permission from H. Liang et al. Nano Lett. 2018; 18; 4460-4466. Copyright © 2018, American Chemical Society [8] . (d) Chiral metamaterial fabricated by electron beam lithography. Scale bar: 500 nm. Reprinted with permission from [9] Copyright © 2007, Optical Society of America. (e) Fishnet structure metamaterial fabricated by nanoimprint lithography. Reprinted with permission from W. Wu et al. Appl. Phys. A 2007; 87; 143-150. Copyright © 2007, Springer-Verlag [10] . (f) Scanning electron microscope images of hyperbolic metamaterials composed of silver/germanium multilayers, shown with two, three, and four pairs of layers, respectively. Reprinted with permission from X. Yang et al. Nat. Photonics 2012; 6; 450-454. Copyright © 2012, Springer Nature Limited [11] .
Keywords: 바이오 메디컬 이미징, 하이퍼렌즈, 메타렌즈, 메타물질
OCIS codes: (160.3918) Metamaterials; (170.3880) Medical and biological imaging; (220.0220) Optical design and fabrication
초록
바이오 메디컬 이미징 기술은 생물학적 연구 및 의료 기술에 사용되는 이미징 기법으로서 생물학적 과정, 구조 및 상태를 탐구하는 데 필수이 며, 질병의 조기 진단과 치료법 개발에도 중요한 역할을 하고 있다. 그중에서도 특히 빛을 이용한 광학 이미징 기술은 생물학 연구에서 가장 많이 활용되고 활발하게 연구되고 있다. 광학 이미징 기술의 발전에 가장 큰 걸림돌이 되고 있는 것은 해상도 및 빛의 투과 깊이 한계 등의 문제 인데, 최근에는 메타물질을 이용하여 이를 해결하고자 하는 연구가 활발해지고 있는 추세이다. 메타물질은 나노구조체의 규칙적인 배열을 통해 빛의 성질을 자유롭게 조절하는 물질로서, 이미징 분야에서는 이미 혁신적인 도구로 자리잡고 있다. 이 글에서는 메타물질을 활용한 광학 이미징 기술의 작동 원리와 주요 응용 사례에 대해 자세히 소개하고자 한다
Abstract
Biomedical imaging technologies refer to imaging techniques used in biological research and medical technology that are essential for exploring biological processes, structures, and conditions. They also play a crucial role in the early diagnosis of diseases and the development of treatments. Optical imaging technologies, in particular, are the most widely used and actively researched in biological studies. The major obstacles to technological advancement are the limitations in resolution and light penetration depth. Recently, many technologies have been studied to overcome these limitations using metamaterials. These are materials that can freely manipulate the properties of light through the regular arrangement of nanostructures and have established themselves as innovative tools in the imaging field. This article aims to provide a detailed introduction to the working principles and key applications of these technologies.
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[Editor's Pick] Current Optics and Photonics Vol. 8 no. 4 (2024 August)
Utilizing Optical Phantoms for Biomedical-optics Technology:Recent Advances and Challenges
Ik Hwan Kwon1†, Hoon-Sup Kim1†, Do Yeon Kim1,2†, Hyun-Ji Lee1,3†, and Sang-Won Lee1,3,4 *
Current Optics and Photonics Vol. 8 No. 4 (2024 August), pp. 327-344
DOI: https://doi.org/10.3807/COPP.2024.8.4.327
Fig. 1 Phantoms of optical coherence tomography (OCT) for image calibration and functional quality test. (a) The OCT image and graphs of a single-layer phantom. The nano phantom consists of ultra violet (UV)-curing epoxy and nano-shells to compare the performance of the four OCT systems. Reprinted with permission from A. Fouad et al. Biomed. Opt. Express [1]. Copyright © 2014, Optica Publishing Group. (b) Schematic and OCT images of multi-layer phantoms. Reprinted with permission from A.Agrawal et al. Biomed. Opt. Express [3]. Copyright © 2013, Optica Publishing Group. (c) Wave propagation pattern of phantom from optical coherence elastography. Reprinted from S. Song et al. J. Biomed. Opt. 2013; 18; 21509. Copyright © 2013, SPIE [60]. (d) Spectroscopic OCT image and map of spectroscopic metrics of the phantom. See the main text for details. Reprinted with permission from V. Jaedicke et al. Biomed. Opt. Express [37]. Copyright © 2013, Optica Publishing Group.
Keywords: Calibration, Evaluation, Optical phantom, Tissue-mimic
OCIS codes: (120.4800) Optical standards and testing; (170.0110) Imaging systems; (170.0170) Medical optics and biotechnology; (170.3890) Medical optics instrumentation;(220.0220) Optical design and fabrication
Abstract
Optical phantoms are essential in optical imaging and measurement instruments for performance evaluation, calibration, and quality control. They enable precise measurement of image resolution, accuracy, sensitivity, and contrast, which are crucial for both research and clinical diagnostics. This paper reviews the recent advancements and challenges in phantoms for optical coherence tomography, photoacoustic imaging, digital holographic microscopy, optical diffraction tomography, and oximetry tools. We explore the fundamental principles of each technology, the key factors in phantom development, and the evaluation criteria. Additionally, we discuss the application of phantoms used for enhancing opticalimage quality. This investigation includes the development of realistic biological and clinical tissuemimicking phantoms, emphasizing their role in improving the accuracy and reliability of optical imaging and measurement instruments in biomedical and clinical research.
